Two sample MR report
HLA-DRB5_Dendritic Cell (DC) against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 25 | 0.0940764 | 0.1067708 | 0.3873756 |
| Weighted median | 25 | 0.0864197 | 0.0235704 | 0.0002459 |
| Inverse variance weighted | 25 | 0.0679537 | 0.0177704 | 0.0001313 |
| Simple mode | 25 | 0.0959862 | 0.0431941 | 0.0359496 |
| Weighted mode | 25 | 0.0925806 | 0.0437147 | 0.0447395 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 13.60221 | 23 | 0.9376992 |
| Inverse variance weighted | 13.66377 | 24 | 0.9538834 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0105834 | 0.0426541 | 0.8062423 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0003139 | 0 | TRUE | 0.0930459 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
